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Dose selection for the treatment of metastatic renal cell carcinoma
The patient was admitted for treatment of advanced disease with a tumor. Her symptoms and signs were consistent with malignancy, but there was no previous history of renal cancer. The patient and family agreed that she should commence radiotherapy, but chose to be managed with surgery because of the uncertainty surrounding prognosis and risks, including radiation surgery. There is a limited evidence on radiation dose response, but a recent meta-analysis showed that radiotherapy at 3.6 Gy was associated with a significant (RR = 1.38) relative survival difference to a conventional treatment strategy. The patient was treated twice after the standard doses. She started first with the lowest-dose therapy, which had goal to achieve 90% disease response, at an initial dose of 100 Gy. The second dose was also given at 100 Gy. The treatment was given every other week for a maximum of eight cycles, with a maximum of seven cycles per patient. At the time of this study, overall survival rate for renal cell carcinoma treated in North America at 14 months (n = 634) did not exceed 70%, and in the National Research Council Clinical Trials Registry at 13 years (n = 564) survival did not exceed 80%.
At three months after completion of the first radiation dose, a small tumor was detectable and radiographic imaging showed the cancer had undergone aggressive tumor consolidation. The patient was then treated with a second dose of radium to achieve 100 Gy in the right renal pelvis and to
Eprosartan cost establish a dose of 110 Gy in the left renal pelvis at two months after initial dose. Both patients were monitored throughout this second radiographic session, and as soon there were indications that the progression was being arrested, patients were admitted for a maximum of two days to the cancer institute. Both patients were given neoadjuvant or adjuvant chemotherapy to achieve an overall survival rate of 85% at three years.
At the time of surgery, both patients appeared to be responding well the treatment, with radiographic confirmation of tumor consolidation and improvement in clinical signs symptoms. The primary reason for surgery was to remove a resected tumor and its surrounding fibrogenitic mass. The secondary cause of surgery was to eliminate a nodular nodule, which, though smaller than it appeared before the operation, was associated with significant morbidity and radiation exposure risks. Both nephrologists agreed that it was most preferable an alternative treatment and adjuvant chemotherapy could be given in combination with the standard therapy, which was to continue in the presence of a progressive renal tumor without additional radiotherapy.
The initial radiotherapy dose was 80 Gy, and subsequent doses at 60 Gy online pharmacy uk accutane were performed six-month intervals. When two doses of radiation in each patient, administered the order previously suggested, demonstrated no benefit, the maximum daily dose was reduced to 90 Gy. This was in accordance with current guideline recommendations from the Canadian Nuclear Laboratories (Canadian Radiotherapy Society, 2004), North American Society of Kidney Dialysis and Renal Transplant (NASHRU; 2004), American Joint Committee on Cancer – Oncology (American Joint National Committee on Cancers; 2004).
The primary outcome was overall survival, to which an important consideration is the presence of a tumor